A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of Risedronate Sodium Hemi-pentahydrate (RSHPH). The stationary phase used was precoated silica gel 60F (254). The mobile phase used was a mixture of Water: Methanol: 25 % Ammonia (100:15:15) v/v/v). The detection of spots was carried out at 266 nm. The method was validated in terms of linearity, accuracy, precision and specificity. The calibration curve was found to be linear between 3 to 6 µg/spot for RSHPH. The limit of detection and the limit of quantification for the RSHPH were found to be 0.6945 and 2.1046 respectively. The proposed method can be successfully used to determine the drug content of marketed formulation.
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